- Title
- Temporospatial guidance of activity-dependent gene expression by microRNA: mechanisms and functional implications for neural plasticity
- Creator
- Kiltschewskij, Dylan; Cairns, Murry J.
- Relation
- NHMRC.1067137 http://purl.org/au-research/grants/nhmrc/1067137
- Relation
- Nucleic Acids Research Vol. 47, Issue 2, p. 533-545
- Publisher Link
- http://dx.doi.org/10.1093/nar/gky1235
- Publisher
- Oxford University Press
- Resource Type
- journal article
- Date
- 2019
- Description
- MicroRNA are major regulators of neuronal gene expression at the post-transcriptional and translational levels. This layer of control is critical for spatially and temporally restricted gene expression, facilitating highly dynamic changes to cellular structure and function associated with neural plasticity. Investigation of microRNA function in the neural system, however, is at an early stage, and many aspects of the mechanisms employing these small non-coding RNAs remain unclear. In this article, we critically review current knowledge pertaining to microRNA function in neural activity, with emphasis on mechanisms of microRNA repression, their subcellular remodelling and functional impacts on neural plasticity and behavioural phenotypes.
- Subject
- gene expression; microRNA; mechanisms; neural plasticity
- Identifier
- http://hdl.handle.net/1959.13/1423936
- Identifier
- uon:37997
- Identifier
- ISSN:0305-1048
- Rights
- © The Author(s) 2018. Published by Oxford University Press on behalf of Nucleic Acids Research. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
- Language
- eng
- Full Text
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